Just replace each instance of "iframe" with "amp-iframe" like this example:
<div style="position:relative; width:1px; min-width:100%; padding-bottom:56.25%"><amp-iframe allow="autoplay" class="spotlightr" allowtransparency="true" style="width:1px; min-width:100%; height: 100%; position:absolute" allowfullscreen="true" src="https://demo.cdn.spotlightr.com/watch/MTE1OTY2Mg==?fallback=true" frameborder="0" scrolling="no" name="videoPlayerframe"> </amp-iframe></div>